Why the study?
Does alpha-hANP infusion alter cardiovascular and renal function in conscious dogs?
Population
Conscious dogs
Comparison
Intravenous infusion of alpha-human atrial… vs Preinfusion baseline values
Design
Preclinical
Follow-up
Up to 1 hour
Authors
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Modest natriuretic effects in dogs suggest limited ANP dominance; leaves open translation to human volume regulation.
Does alpha-hANP infusion alter cardiovascular and renal function in conscious dogs?
Low-dose infusions of atrial natriuretic peptide in conscious dogs decrease cardiac filling pressures and modestly increase sodium excretion, suggesting a modulatory rather than dominant physiological role in sodium regulation.
Bie et al. (1988) studied this question.
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