Key Points
- To examine the systemic hemodynamic, renal, and hormonal effects of graded infusions of α-human atrial natriuretic polypeptide (α-hANP) in healthy individuals.
- Administered graded intravenous infusions of α-hANP to 11 healthy male volunteers.
- Assessed blood pressure, heart rate, glomerular filtration rate, renal blood flow, urine output, and urinary sodium excretion.
- Measured plasma concentrations of renin activity, norepinephrine, aldosterone, cortisol, and arginine vasopressin, alongside hematocrit.
- Infusion produced a dose-dependent decrease in blood pressure and an increase in heart rate, but caused no significant changes in urine volume, urinary sodium excretion, or glomerular filtration rate.
- Renal blood flow decreased while renal vascular resistance and filtration fraction significantly increased, accompanied by a small but significant rise in hematocrit.
- Plasma renin activity and norepinephrine increased significantly (both p<0.001), while plasma aldosterone and cortisol dropped significantly (both p<0.001), and arginine vasopressin surged following infusion cessation.
Structured PICO
Does intravenous infusion of α-hANP alter blood pressure, renal hemodynamics, and endocrine profiles in healthy male volunteers?
PPopulation11 healthy male volunteers
IInterventionIntravenous infusion of graded doses of α-human atrial natriuretic polypeptide (α-hANP)
OOutcomeBlood pressure and heart ratesurrogate
In healthy normotensive men, α-hANP infusion lowers blood pressure and inhibits aldosterone and cortisol secretion, but does not induce significant diuresis or natriuresis, likely due to the predominant hypotensive effect.
Limitations
- A diurnal change may have served to obscure a diuretic and natriuretic response