What question did this study set out to answer?

This research aims to understand how atrial natriuretic peptide affects renal and hormonal responses based on sodium intake in normal individuals.

October 1, 1986The Journal of Clinical Endocrinology & Metabolism

Renal, Hemodynamic, and Hormonal Responses to Atrial Natriuretic Peptide Infusions in Normal Man, and Effect of Sodium Intake*

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Why the study?

Does alpha-human atrial natriuretic peptide infusion alter renal, hemodynamic, and hormonal responses in normal men under different sodium intakes?

Population

6 normal men

Comparison

60-min constant intravenous infusions of… vs Control infusions given on the preceding day for…

Design

Other

Follow-up

60 minutes (infusion duration)

Authors

RCRoss C. CuneoGuy's Hospital EEEric A. EspinerHeart Failure / Cardiomyopathy MNM. Gary NichollsTulane University

Discussion

Member takes

Implication

ANP natriuresis is salt-dependent in normals; leaves open whether similar modulation applies in heart failure or hypertension.

Key Points

This research aims to understand how atrial natriuretic peptide affects renal and hormonal responses based on sodium intake in normal individuals.
Conducted constant intravenous infusions of alpha hANP (200 micrograms) for 60 minutes on high and low sodium diets.
Monitored plasma concentrations and renal outputs (sodium, urine volume, hormones).
Compared responses to control infusions on the preceding day.
Infusions of alpha hANP increased sodium excretion by over threefold during high salt diet.
During low salt diet, natriuresis was only 11% of that observed during high salt diet, despite continued diuretic effects.
Significant decreases in plasma renin activity and aldosterone were noted during both dietary conditions with alpha hANP administration.

Structured PICO

Does alpha-human atrial natriuretic peptide infusion alter renal, hemodynamic, and hormonal responses in normal men under different sodium intakes?

Population

6 normal men

Intervention

60-min constant intravenous infusions of alpha-human atrial natriuretic peptide (alpha hANP; 200 micrograms) after equilibration on a high sodium diet (200 mmol daily) and a low sodium diet (10 mmol daily)

Comparator

Control infusions given on the preceding day for each diet condition

Outcome

Renal (sodium, calcium, magnesium excretion, urine volume), hemodynamic (blood pressure, heart rate), and hormonal (norepinephrine, renin, aldosterone, angiotensin II, cortisol, arginine vasopressin) responsessurrogate

Alpha-human atrial natriuretic peptide significantly increases sodium excretion and inhibits the renin-angiotensin-aldosterone system in normal men, though its natriuretic effects are markedly blunted by sodium depletion.

Cite This Study

Cuneo et al. (1986) studied this question.

synapsesocial.com/papers/6a71547ea528af2d65c40690 https://doi.org/10.1210/jcem-63-4-946

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Renal, Hemodynamic, and Hormonal Responses to Atrial Natriuretic Peptide Infusions in Normal Man, and Effect of Sodium Intake*

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Renal, Hemodynamic, and Hormonal Responses to Atrial Natriuretic Peptide Infusions in Normal Man, and Effect of Sodium Intake*

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider