What does this research mean for the field?

The diuretic and natriuretic effects of human atrial natriuretic peptide (hANP) in healthy men are transient and wane during prolonged continuous administration. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study investigates the effects of human atrial natriuretic peptide on urinary flow and sodium excretion in healthy men.

May 1, 1986The Journal of Clinical Endocrinology & Metabolism

Prolonged Administration of Human Atrial Natriuretic Peptide in Healthy Men: Evanescent Effects on Diuresis and Natriuresis

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Why the study?

Does prolonged administration of human atrial natriuretic peptide (hANP) induce sustained diuresis and natriuresis in healthy men?

Population

6 normal sodium- and fluid-replete men

Design

Other

Follow-up

6 hours

Authors

WWW. WaldhäuslMedical University of Vienna HVH VierhapperUniversity of Vienna PNP. NowotnyDeutsches Diabetes-Zentrum e.V.

Discussion

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Implication

Prolonged hANP yields only transient diuresis in healthy men; leaves open efficacy in clinical heart failure populations.

Key Points

The study investigates the effects of human atrial natriuretic peptide on urinary flow and sodium excretion in healthy men.
Synthetic hANP was given as an iv bolus and continuous infusion to six healthy men.
Participants received varying doses (25-175 micrograms) and infusion protocols over 6 hours.
Urinary flow and excretion rates of sodium and chloride were measured alongside blood pressure monitoring.
Urinary flow and sodium excretion increased during protocols with higher hANP doses, but effects diminished after 6 hours.
Blood pressure decreased only with protocols using higher continuous doses of hANP.
Plasma aldosterone concentrations decreased following administration of 175 micrograms hANP or more.

Structured PICO

Does prolonged administration of human atrial natriuretic peptide (hANP) induce sustained diuresis and natriuresis in healthy men?

Population

6 normal sodium- and fluid-replete men

Intervention

Synthetic human atrial natriuretic peptide (hANP) administered via IV bolus and/or continuous infusion for 6 hours across 4 different dosing protocols

Outcome

Urinary flow rates and excretion rates of sodium and chloridesurrogate

Prolonged continuous administration of human atrial natriuretic peptide in healthy men produces only transient diuretic and natriuretic effects that are not maintained over time.

Cite This Study

Waldhäusl et al. (1986) studied this question.

synapsesocial.com/papers/6a1c1b87ea84844e355f74bb https://doi.org/10.1210/jcem-62-5-956

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Prolonged Administration of Human Atrial Natriuretic Peptide in Healthy Men: Evanescent Effects on Diuresis and Natriuresis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Prolonged Administration of Human Atrial Natriuretic Peptide in Healthy Men: Evanescent Effects on Diuresis and Natriuresis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider