Why the study?
Does low dose infusion of human atrial natriuretic peptide alter renal function and electrolyte excretion in healthy volunteers?
Population
7 healthy volunteers undergoing a water diuresis
Design
Other
Follow-up
3 hours
Authors
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Supports selective natriuresis models; leaves open therapeutic translation to edematous states.
Does low dose infusion of human atrial natriuretic peptide alter renal function and electrolyte excretion in healthy volunteers?
Low-dose hANP infusion promotes diuresis and natriuresis in healthy humans, likely through distal nephron effects and suppression of the renin-aldosterone axis.
Solomon et al. (1988) studied this question.
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