What question did this study set out to answer?

To investigate the effects of low dose atrial natriuretic peptide (ANP) infusion on salt and water excretion in normal volunteers.

April 1, 1988Clinical Science

Low dose infusion of atrial natriuretic peptide causes salt and water excretion in normal man

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Why the study?

Does low dose infusion of atrial natriuretic peptide increase salt and water excretion in fluid-loaded normal volunteers?

Population

6 fluid-loaded normal volunteers

Comparison

Atrial natriuretic peptide infusion in hourly… vs Placebo

Design

RCT, double-blind

Follow-up

hours (hourly increments)

Authors

AMAlyn H. MoriceCastle Hill Hospital JPJoanna Pepke‐ŻabaVascular / Pulmonary Vascular ELE LoysenAddenbrooke's Hospital

Discussion

Member takes

Implication

ANP promotes natriuresis at near-physiological doses in humans; confirms its hormonal role in salt and water homeostasis.

Key Points

To investigate the effects of low dose atrial natriuretic peptide (ANP) infusion on salt and water excretion in normal volunteers.
Conducted a double-blind, placebo-controlled study with six fluid-loaded volunteers.
Infused hourly increments of ANP at doses of 0.4, 2, and 10 pmol min-1 kg-1 and measured physiological responses.
Estimated plasma ANP, aldosterone, catecholamines, urinary volume, and sodium excretion at half-hourly intervals.
Urinary sodium excretion increased by 35%, 98%, and 207% compared to placebo at doses of 0.4, 2, and 10 pmol min-1 kg-1 respectively.
Urinary volume increased by 10%, 20%, and 71% compared to placebo at the same doses.
No significant changes in heart rate or blood pressure; stroke volume index decreased during treatment.

Structured PICO

Does low dose infusion of atrial natriuretic peptide increase salt and water excretion in fluid-loaded normal volunteers?

Population

6 fluid-loaded normal volunteers

Intervention

Atrial natriuretic peptide (ANP) infusion in hourly increments of 0.4, 2, and 10 pmol min-1 kg-1

Comparator

Placebo

Outcome

Urinary sodium excretion and urinary volumesurrogate

Low dose infusion of atrial natriuretic peptide produces potent natriuretic and diuretic effects at near-physiological plasma concentrations, suggesting a hormonal role in salt and water homeostasis.

Cite This Study

Morice et al. (1988) studied this question.

synapsesocial.com/papers/6a71547ea528af2d65c4068c https://doi.org/10.1042/cs0740359

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Low dose infusion of atrial natriuretic peptide causes salt and water excretion in normal man

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Low dose infusion of atrial natriuretic peptide causes salt and water excretion in normal man

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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