Key result
Infusion of synthetic ANP at 20 ng.kg-1.min-1 in anesthetized rats produced significant natriuresis and diuresis, increasing plasma ANP to 279 pmol/l compared to 158 pmol/l in controls.
Population
Anesthetized euvolemic and volume-expanded rats
Comparison
Synthetic ANP- infusion at rates ranging between… vs Control rats
Design
Preclinical
Follow-up
30 min
Authors
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Should not change clinical practice; extends rodent data on physiological ANP thresholds for natriuresis.
Absolute Event Rate: 279% vs 158%
Physiological increases in plasma ANP concentration are sufficient to induce natriuresis and diuresis, whereas changes in GFR and blood pressure require higher, non-physiological doses.
Soejima et al. (1988) studied Anesthetized euvolemic and volume-expanded rats. Synthetic ANP-(4-28) vs. Control rats was evaluated on Plasma ANP levels at 20 ng.kg-1.min-1 infusion. Infusion of synthetic ANP at 20 ng.kg-1.min-1 in anesthetized rats produced significant natriuresis and diuresis, increasing plasma ANP to 279 pmol/l compared to 158 pmol/l in controls.
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