January 1, 1987Japanese Heart JournalOpen Access

Effects of atrial natriuretic peptide on renal function and renin release in the isolated perfused rat kidney.

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Population

Isolated perfused rat kidney (IPK) model

Comparison

Synthetic atrial natriuretic peptide 10 mol… vs ANP-free control group

Design

Preclinical

Authors

Discussion

ANP renal effects in rat models merit human translation studies; leaves open clinical relevance beyond isolated kidney preparations.

Population

Isolated perfused rat kidney (IPK) model

Intervention

Synthetic atrial natriuretic peptide (ANP) 10(-9) mol administered in 75 ml of perfusate (with or without indomethacin or mefenamic acid)

Comparator

ANP-free control group

Outcome

Renal hemodynamics, glomerular filtration rate (GFR), fluid and electrolyte excretion, and renin releasesurrogate

In an isolated perfused rat kidney model, synthetic ANP induces prostaglandin-independent natriuresis and suppresses renin release.

Narumi et al. (1987) studied this question.

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