Why the study?
Does human alpha-ANP infusion at physiological concentrations increase natriuresis and diuresis in normal subjects?
Population
7 water-loaded normal subjects
Comparison
Infusion of human alpha-ANP at a calculated rate… vs Infusion of the vehicle alone on a separate…
Design
Other
Follow-up
3 hours
Authors
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Physiological ANP infusion augments natriuresis in normals; supports its hormonal role but leaves therapeutic translation open.
Does human alpha-ANP infusion at physiological concentrations increase natriuresis and diuresis in normal subjects?
Infusion of ANP to achieve physiological plasma concentrations causes significant natriuresis and diuresis in normal humans, supporting its role as a physiological natriuretic hormone.
Anderson et al. (1987) studied this question.
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