December 1, 1988The Journal of Clinical Endocrinology & Metabolism
Atrial Natriuretic Hormone Has Biological Effects in Man at Physiological Plasma Concentrations*
Why the study?
Does a low-dose infusion of human atrial natriuretic factor induce biological effects at physiological plasma concentrations in normal men?
Population
6 normal men on a normal sodium intake
Comparison
3-hour low dose infusion of human atrial… vs Placebo infusion
Design
RCT, random order, single blind
Follow-up
3 hours
Authors
Discussion
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Implication
ANF exerts effects at physiological levels in humans; confirms its regulatory role and guides therapeutic peptide research.
Key Points
- This research aims to determine the biological effects of atrial natriuretic hormone (ANH) at physiological plasma concentrations in humans.
- Conducted a single blind, placebo-controlled study with six normal men.
- Infused ANF at a low dose of 0.75 pmol/kg.min for 3 hours during normal sodium intake.
- Measured changes in plasma ANH, urinary excretion, plasma aldosterone, and blood pressure.
- Plasma ANH levels increased within normal ranges, leading to a significant rise in urinary excretion of sodium, magnesium, calcium, and cGMP.
- Plasma renin activity decreased to 50% and plasma aldosterone decreased to 64% of placebo values.
- Systolic and mean arterial pressures showed a significant reduction during ANH infusion.
Structured PICO
Does a low-dose infusion of human atrial natriuretic factor induce biological effects at physiological plasma concentrations in normal men?
P
Population
6 normal men on a normal sodium intake
I
Intervention
3-hour low dose infusion of human atrial natriuretic factor (ANF) at 0.75 pmol/kg.min (0.0023 micrograms/kg.min)
C
Comparator
Placebo infusion
O
Outcome
Changes in urinary excretion of sodium, magnesium, calcium, and cGMP, plasma renin activity (PRA), plasma aldosterone concentrations, and blood pressuresurrogate
Atrial natriuretic hormone exerts significant biological effects on renal excretion, renin-aldosterone suppression, and blood pressure reduction at physiological plasma concentrations.
Cite This Study
Richards et al. (1988) studied this question.