Why the study?
Does physiological infusion of atrial natriuretic hormone (ANH) affect aldosterone levels and salt/water metabolism in normal young men under varying salt intake and ACE inhibition?
Population
10 normal young men
Comparison
Infusion of 0.6 pmol/kg.min human [Ser,Tyr28]ANH… vs Comparison across the 3 study conditions and…
Design
Other
Follow-up
2 hours of infusion plus 1 hour of recovery
Authors
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ANH suppresses aldosterone in a salt-dependent manner in healthy men; leaves open its role in hypertension or HF management.
Does physiological infusion of atrial natriuretic hormone (ANH) affect aldosterone levels and salt/water metabolism in normal young men under varying salt intake and ACE inhibition?
Physiological increases in atrial natriuretic hormone suppress aldosterone primarily through indirect mechanisms and regulate water metabolism in normal men.
Clinkingbeard et al. (1990) studied this question.
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