Key result
Infusion of alpha-human ANF in normal men on a low sodium diet maintained plasma ANF at 16.1 pmol/L compared to 7 pmol/L in controls, but did not alter cumulative negative sodium balance.
Why the study?
Does alpha-human ANF infusion alter the hormonal and renal adaptation to sodium deficiency in normal male volunteers?
Population
5 normal male volunteers on a low sodium diet (15 mmol Na+/day) following a high sodium period (250 mmol/day)
Comparison
alpha-human ANF iv infusion at a low dose for 6… vs sodium restriction without ANF infusion
Design
Other
Follow-up
6 days
Authors
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ANF infusion at physiological levels does not modify sodium adaptation in normals; leaves open effects in disease states or at higher doses.
Does alpha-human ANF infusion alter the hormonal and renal adaptation to sodium deficiency in normal male volunteers?
Absolute Event Rate: 16.1% vs 7%
Chronic low-dose ANF infusion does not significantly alter the long-term renal and hormonal adaptation to dietary sodium restriction in normal humans.
Beland et al. (1994) studied Normal male volunteers on a low sodium diet (n=5). alpha-human ANF vs. sodium restriction without ANF infusion was evaluated on Plasma ANF level. Infusion of alpha-human ANF in normal men on a low sodium diet maintained plasma ANF at 16.1 pmol/L compared to 7 pmol/L in controls, but did not alter cumulative negative sodium balance.
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