What does this research mean for the field?

The transient nature of diuresis induced by prolonged administration of human atrial natriuretic peptide (hANP) is not caused by the peptide's hypotensive effect, as counterbalancing the hypotension with norepinephrine fails to prevent the decline in diuresis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to explore the diuretic effect of human atrial natriuretic peptide (hANP) and its interactions with norepinephrine in healthy men.

December 1, 1987European Journal of Clinical Investigation

Prolonged administration of human atrial natriuretic peptide in healthy men: evanescent effect on diuresis in spite of simultaneous infusion of norepinephrine

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Why the study?

Does concomitant infusion of norepinephrine prevent the evanescent diuretic effect of prolonged hANP infusion in healthy men?

Key Points

This research aims to explore the diuretic effect of human atrial natriuretic peptide (hANP) and its interactions with norepinephrine in healthy men.
Six healthy men received a prolonged infusion of hANP and norepinephrine over six hours.
The study measured diuresis and plasma concentrations of hANP during the infusions.
There was a transient increase in diuresis with hANP but not sustained throughout the infusion.
Norepinephrine infusion did not prevent the decrease in diuresis toward the end of the hANP infusion.
Plasma concentrations of hANP remained elevated and unaffected by norepinephrine.

Structured PICO

Does concomitant infusion of norepinephrine prevent the evanescent diuretic effect of prolonged hANP infusion in healthy men?

Population

Healthy, sodium and fluid replete men (n = 6)

Intervention

Concomitant infusion of norepinephrine (50 ng kg-1 min-1) during prolonged infusion of human atrial natriuretic peptide (hANP: 50 micrograms h-1 for 6 h)

Comparator

Prolonged infusion of human atrial natriuretic peptide alone

Outcome

Diuresis over the 6-hour infusion periodsurrogate

The transient diuretic effect of prolonged hANP infusion is not caused by its hypotensive action, as counterbalancing blood pressure with norepinephrine does not sustain diuresis.

Authors

HVH VierhapperUniversity of Vienna PNP. NowotnyDeutsches Diabetes-Zentrum e.V.

Discussion

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Implication

Rules out hypotension as cause of transient hANP diuresis; leaves open alternative mechanisms for study in healthy subjects.

Cite This Study

Vierhapper et al. (1987) studied this question.

synapsesocial.com/papers/6a1bd1876f692abb725eea48 https://doi.org/10.1111/j.1365-2362.1987.tb01155.x

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Prolonged administration of human atrial natriuretic peptide in healthy men: evanescent effect on diuresis in spite of simultaneous infusion of norepinephrine

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Prolonged administration of human atrial natriuretic peptide in healthy men: evanescent effect on diuresis in spite of simultaneous infusion of norepinephrine

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider