Key result
Intravenous or direct kidney infusion of rat atrial myocardium extract caused massive diuresis and natriuresis in anesthetized rats, independent of prostaglandin synthesis.
Why the study?
Does atrial natriuretic factor induce diuresis and natriuresis independently of prostaglandin synthesis in anesthetized rats?
Population
Anesthetized rats
Design
Preclinical
Follow-up
short duration
Authors
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No immediate clinical implications; leaves open the factor's identity and relevance to human physiology.
Does atrial natriuretic factor induce diuresis and natriuresis independently of prostaglandin synthesis in anesthetized rats?
This study provides early evidence that atrial natriuretic factor acts directly on the kidneys to induce diuresis and natriuresis independently of prostaglandins.
R. Keeler (1982) studied this question. Saline extract of lyophilized rat atrial myocardium was evaluated on Diuresis and natriuresis. Intravenous or direct kidney infusion of rat atrial myocardium extract caused massive diuresis and natriuresis in anesthetized rats, independent of prostaglandin synthesis.
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