Why the study?
Does synthetic human atrial 28-amino acid peptide alter systemic and renal hemodynamics in anesthetized rats?
Population
Inactin-anesthetized rats (two separate groups)
Comparison
Infusion of synthetic human atrial 28-amino acid… vs Baseline (before infusion)
Design
Preclinical
Follow-up
10 minutes of infusion
Authors
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No immediate clinical implications; leaves open translation of ANP effects to human cardiovascular therapy.
Does synthetic human atrial 28-amino acid peptide alter systemic and renal hemodynamics in anesthetized rats?
Synthetic human atrial natriuretic peptide induces dose-dependent reductions in blood pressure and marked diuresis and natriuresis in anesthetized rats.
Hirata et al. (1985) studied this question.
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