Effects of synthetic atrial natriuretic peptide on renal function and renin release in acute experimental heart failure.
Why the study?
Does synthetic atrial natriuretic peptide alter renal function and renin release in a canine model of acute low-output heart failure?
Population
Anesthetized dogs, including a control group and a group with acute low-output heart failure produced by…
Comparison
Intrarenal infusion of synthetic atrial… vs Control dogs without heart failure receiving the…
Design
Preclinical
Authors
Discussion
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Implication
Blunted natriuresis to ANP in acute HF despite preserved GFR/renin effects; hypothesis-generating for renal resistance mechanisms in clinical heart failure.
Structured PICO
Does synthetic atrial natriuretic peptide alter renal function and renin release in a canine model of acute low-output heart failure?
P
Population
Anesthetized dogs, including a control group (n=6) and a group with acute low-output heart failure produced by inflation of a balloon in the thoracic inferior vena cava (n=6).
I
Intervention
Intrarenal infusion of synthetic atrial natriuretic peptide (0.3 micrograms/kg/min)
C
Comparator
Control dogs without heart failure receiving the same infusion
O
Outcome
Renal function (glomerular filtration rate, fractional lithium excretion, urinary sodium excretion, fractional excretion of sodium) and renin release (renin secretory rate)surrogate
In an acute canine model of heart failure, synthetic atrial natriuretic peptide increases GFR and decreases renin release, but its natriuretic effect is blunted compared to healthy controls.
Cite This Study
Scriven et al. (1985) studied this question.