Population
Normal dogs (n=6) and dogs with nonfiltering kidneys (n=8)
Comparison
Intrarenal infusion of synthetic atrial… vs Baseline and adenosine infusion
Design
Preclinical
Authors
Loading...
ANP-renin effects may require intact macula densa; extends animal mechanisms but leaves open human relevance and should not change practice.
Atrial natriuretic peptide requires a functional macula densa to inhibit renin secretion, as demonstrated by its lack of effect in a nonfiltering kidney model.
Opgenorth et al. (1986) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: