Why the study?
Does human atrial natriuretic peptide alter renal and depressor activities in chronically hypertensive dogs compared to sham dogs?
Population
Conscious one-kidney, one clip dogs with chronic hypertension and modest renal dysfunction (mild proteinuria)
Comparison
Human atrial natriuretic peptide- at 10, 50, and… vs One-kidney sham dogs
Design
Preclinical
Authors
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Attenuated natriuresis in hypertensive dogs despite ANP elevation is hypothesis-generating; leaves open relevance to human hypertension.
Does human atrial natriuretic peptide alter renal and depressor activities in chronically hypertensive dogs compared to sham dogs?
Chronically hypertensive dogs exhibit an attenuated natriuretic response to atrial natriuretic peptide, likely due to downregulation of guanylate cyclase-linked receptors and impaired cGMP signal transduction.
Seymour et al. (1995) studied this question.
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