March 1, 1986HypertensionOpen Access

A comparison of synthetic rat and human atrial natriuretic factor in conscious dogs.

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Why the study?

Does synthetic rat atrial natriuretic factor produce similar renal and hypotensive responses compared to synthetic human atrial natriuretic factor in conscious dogs?

Population

5 conscious dogs

Comparison

Intravenous infusions of 10, 50, 100, and 200… vs Intravenous infusions of synthetic human atrial…

Design

Preclinical

Authors

ASAndrea A. SeymourMerck & Co., Inc., Rahway, NJ, USA (United States)SSShaler G. SmithMerck & Co., Inc., Rahway, NJ, USA (United States)EME K MazackUnited States Military Academy

Discussion

Member takes

Implication

Rat-human ANF equivalence in dogs supports preclinical model validity; leaves open translation to human hypertension therapy.

Structured PICO

Does synthetic rat atrial natriuretic factor produce similar renal and hypotensive responses compared to synthetic human atrial natriuretic factor in conscious dogs?

Population

5 conscious dogs

Intervention

Intravenous infusions of 10, 50, 100, and 200 pmol/kg/min of synthetic rat atrial natriuretic factor

Comparator

Intravenous infusions of synthetic human atrial natriuretic factor at the same doses

Outcome

Renal and hypotensive responses (mean arterial pressure, fractional sodium excretion, urine volume, fractional chloride excretion, fractional potassium excretion, glomerular filtration rate, renal plasma flow)surrogate

Synthetic rat and human atrial natriuretic factors produce similar dose-dependent hypotensive and natriuretic responses in conscious dogs.

Cite This Study

Seymour et al. (1986) studied this question.

synapsesocial.com/papers/6a852e4e22ea7ab258b2e97a https://doi.org/10.1161/01.hyp.8.3.211

View Full Paper

Ask AI

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A comparison of synthetic rat and human atrial natriuretic factor in conscious dogs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A comparison of synthetic rat and human atrial natriuretic factor in conscious dogs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider