December 1, 1998AJP Regulatory Integrative and Comparative Physiology
Vasoconstrictor actions of atrial natriuretic peptide in the splanchnic circulation of anesthetized dogs
Population
Anesthetized dogs
Comparison
Atrial natriuretic peptide infused directly into… vs Baseline
Design
Preclinical
Authors
Discussion
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Implication
ANP may induce splanchnic vasoconstriction; leaves open mechanisms and human relevance, requiring prospective study.
Structured PICO
P
Population
Anesthetized dogs
I
Intervention
Atrial natriuretic peptide (ANP) infused directly into the mesenteric (iMA) and hepatic (iHA) arterial beds (12 ng.kg-1.min-1) or via femoral vein (30 ng.kg-1.min-1)
C
Comparator
Baseline
O
Outcome
Changes in mesenteric and hepatic vascular resistancesurrogate
ANP induces splanchnic vasoconstriction in anesthetized dogs, likely mediated in part by a vasoconstrictor agent released from the intestinal circulation.
Cite This Study
Robyn L. Woods (1998) studied this question.