July 1, 1989AJP Heart and Circulatory Physiology

Effects of ANP on venous pressures and microvascular protein permeability in dog forelimb

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Population

Dog forelimb perfused at constant flow

Comparison

Human alpha-atrial natriuretic peptide injected… vs Acetylcholine, isotonic potassium chloride, or…

Design

Preclinical

Authors

DED. EliadesUniformed Services University of the Health Sciences BSB. T. SwindallUniformed Services University of the Health Sciences JJJamie JohnstonUniversity of Leeds

Discussion

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Implication

ANP lacks direct effects on canine limb veins or permeability; leaves open translational relevance to human cardiovascular regulation.

Structured PICO

Population

Dog forelimb perfused at constant flow

Intervention

Human alpha-atrial natriuretic peptide (ANP) injected and infused into the brachial artery (bolus 0.1-0.4 micrograms; infusion 0.1 ng to 38.8 micrograms/min)

Comparator

Acetylcholine, isotonic potassium chloride, or baseline control levels

Outcome

Large and small vessel pressures in skin and skeletal muscle, limb weight, skin lymph flow, and skin lymph protein concentrationsurrogate

Human alpha-ANP does not directly constrict veins, dilate arterioles, or alter microvascular permeability to plasma proteins in the dog forelimb model.

Cite This Study

Eliades et al. (1989) studied this question.

synapsesocial.com/papers/6a7ec67b2540bc8e230269bb https://doi.org/10.1152/ajpheart.1989.257.1.h272

View Full Paper

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Bookmark

Effects of ANP on venous pressures and microvascular protein permeability in dog forelimb

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of ANP on venous pressures and microvascular protein permeability in dog forelimb

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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