Key result
Intra-arterial bolus injections of atrial natriuretic factor caused graded increases in hepatic arterial blood flow (up to 60-70% over control) without altering portal inflow resistance.
Population
Anaesthetized dogs (hepatic arterial and portal vascular beds)
Comparison
Intra-arterial and intraportal bolus injections… vs Isoprenaline, adrenaline, and control flow
Design
Preclinical
Authors
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Should not change clinical practice; leaves open ANF selectivity for hepatic arterial flow in human studies.
ANF selectively dilates the hepatic arterial bed without affecting portal inflow resistance, potentially favoring trans-sinusoidal fluid exchange.
Withrington et al. (1990) studied this question. Atrial natriuretic factor (ANF) vs. Isoprenaline and adrenaline was evaluated on Hepatic arterial blood flow and portal inflow resistance. Intra-arterial bolus injections of atrial natriuretic factor caused graded increases in hepatic arterial blood flow (up to 60-70% over control) without altering portal inflow resistance.