Population
Conscious dogs
Comparison
Atrial natriuretic factor administered by either… vs Presence vs absence of ganglionic blockade with…
Design
Preclinical
Follow-up
Up to 30 minutes of infusion and recovery period
Authors
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ANF's mode-dependent vascular effects in dogs warrant clinical caution; hypothesis-generating and leaves open human relevance.
ANF elicits differential, dose-dependent vasomotor responses across regional vascular beds in conscious dogs, with transient vasodilation at high bolus doses and vasoconstriction at steady-state infusion levels.
Shen et al. (1991) studied this question.