Why the study?
Does human ANF infusion alter hemodynamics and renal function in conscious dogs?
Does human ANF infusion alter hemodynamics and renal function in conscious dogs?
Physiologically relevant increases in plasma ANF reach diuretic and natriuretic thresholds in conscious dogs without altering systemic hemodynamics.
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Physiologically relevant ANF increases induce diuresis and natriuresis in conscious dogs without hemodynamic changes; extends volume expansion data but leaves human relevance open.
Pichet et al. (1989) studied this question.
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