Why the study?
Does atrial natriuretic factor alter coronary blood flow in anaesthetized dogs?
Population
Anaesthetized dogs with opened chest and cannulated left anterior descending coronary artery perfused at…
Comparison
Atrial natriuretic factor at low dose and high… vs Baseline measurements and control animals…
Design
Preclinical
Authors
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Dose-dependent ANF coronary effects in dogs warrant no clinical extrapolation; leaves open human translation and RAS mechanisms.
Does atrial natriuretic factor alter coronary blood flow in anaesthetized dogs?
ANF exerts dose-dependent effects on coronary blood flow in dogs, causing vasoconstriction at low doses and vasodilation at high doses, with the dilator effect partly mediated by interference with the renin-angiotensin system.
Ertl et al. (1992) studied this question.
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