What question did this study set out to answer?

To determine the contractile effects of physostigmine across the smooth muscle layers of the chicken oesophagus and evaluate the histochemical distribution of cholinesterases.

July 1, 1968British Journal of Pharmacology and ChemotherapyOpen Access

The Action of Physostigmine and the Distribution of Cholinesterases in the Chicken Oesophagus

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Authors

ABA. L. BartletUniversity of Edinburgh THT. HassanChattogram Veterinary and Animal Sciences University

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Implication

Experimental study demonstrates that physostigmine increases muscular tone across oesophageal layers in chickens, indicating smooth muscle cholinesterase modulation.

Key Points

To determine the contractile effects of physostigmine across the smooth muscle layers of the chicken oesophagus and evaluate the histochemical distribution of cholinesterases.
Measured contractile tone in isolated preparations of chicken oesophagus containing external smooth muscle and muscularis mucosae following physostigmine exposure.
Evaluated non-neuronal mechanisms by testing physostigmine-induced responses in the presence of cocaine.
Conducted histochemical localization of cholinesterases across oesophageal tissue layers to identify the site of action.
Physostigmine increased the tone of both the plain external muscle and the muscularis mucosae in isolated chicken oesophageal tissues.
Cocaine exposure and histochemical enzyme mapping characterized the localization of cholinesterases and the contribution of non-neuronal sites to muscle contraction.

Cite This Study

Bartlet et al. (1968) studied this question.

synapsesocial.com/papers/6aa02ee29cb926ef997b2772 https://doi.org/10.1111/j.1476-5381.1968.tb00501.x

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Implication

Experimental study demonstrates that physostigmine increases muscular tone across oesophageal layers in chickens, indicating smooth muscle cholinesterase modulation.

The Action of Physostigmine and the Distribution of Cholinesterases in the Chicken Oesophagus

Discussion

Member takes

Implication

Key Points

Cite This Study

The Action of Physostigmine and the Distribution of Cholinesterases in the Chicken Oesophagus

Discussion

Member takes

Implication

Key Points

Cite This Study

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