Muscarinic cholinergic and preganglionic physiological stimulation increase cyclic GMP levels in guinea pig superior cervical ganglia, whereas norepinephrine has no effect.
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Findings in guinea pig ganglia are hypothesis-generating; leaves open applicability to human autonomic signaling.
Incubation of guinea‐pig superior cervical ganglia in 500μ4mU m ‐carbachol for 2min increased cyclic GMP levels 530% over control values. The increase was blocked by prior incubation in 300μ m atropine. No increase in cyclic GMP levels after incubation in 100 μ m ‐ l ‐norepinephrine was observed. Preganglionic physiological stimulation for 8 min at 10 Hz increased cyclic GMP levels 180% over control values. We conclude that both muscarinic cholinergic and preganglionic physiological stimulation increase cyclic GMP levels in guinea pig superior cervical ganglia, while norepinephrine has no effect.
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Wamsley et al. (1979) studied this question.
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