There is a dissociation between total tissue cyclic GMP content and the electrophysiological effects of acetylcholine in guinea pig atria, suggesting cyclic GMP may not directly mediate these effects.
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Acetylcholine effects on atrial electrophysiology appear cGMP-independent in guinea pig atria; leaves open mechanistic role and requires validation in other models.
Mirro et al. (1979) studied this question.
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