Population
Segments of guinea-pig coronary artery
Comparison
Acetylcholine (ACh) vs NO donor L-nitrosocysteine (Cys-NO)
Design
Preclinical
Authors
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Provides mechanistic insight into coronary relaxation; leaves open translation to human disease and therapy.
Acetylcholine induces relaxation in guinea-pig coronary arteries via both NO-dependent cyclic GMP elevation and an NO-independent hyperpolarizing factor (EDHF).
Eckman et al. (1994) studied this question.
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