Population
Human coronary vessels isolated from nonischemic dilated and ischemic cardiomyopathic hearts
Comparison
Acetylcholine or substance P with or without NO… vs Vessels from nonischemic dilated versus ischemic…
Design
Preclinical
Authors
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Differential NO dependence in ICM vs DCM vessels is hypothesis-generating; leaves open translation to human endothelial function or therapy.
In human epicardial coronary arteries, NO and a secondary endothelium-derived relaxing factor contribute to substance P-induced relaxation in dilated cardiomyopathy, whereas only NO is involved in ischemic cardiomyopathy.
Éric Thorin (2001) studied this question.
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