Why the study?
Do acetylcholine and substance P elicit different endothelium-dependent vasodilation responses in patients with moderate coronary artery disease?
Population
Patients with angiographically moderate coronary artery disease
Authors
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Indicates selective muscarinic endothelial defect in moderate CAD; extends evidence for preserved non-muscarinic EDRF release.
Do acetylcholine and substance P elicit different endothelium-dependent vasodilation responses in patients with moderate coronary artery disease?
In patients with moderate coronary artery disease, atherosclerotic epicardial coronary arteries fail to vasodilate in response to acetylcholine but preserve vasodilation with substance P, indicating a specific muscarinic endothelial defect rather than a total inability to release EDRF.
Bossaller et al. (1989) studied this question.
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