January 7, 1997Circulation
Coronary Vascular Nitric Oxide Activity in Hypertension and Hypercholesterolemia
Why the study?
Do hypertension and hypercholesterolemia impair coronary vascular nitric oxide activity in response to endothelial stimulators in patients with angiographically normal coronary arteries?
Population
26 patients with angiographically normal coronary arteries, including 10 without risk factors and 16 with…
Comparison
Intracoronary dose-response curves with… vs Patients without risk factors and baseline…
Design
Cross-sectional
Authors
Discussion
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Implication
Should not yet change practice; extends acetylcholine findings to nonmuscarinic stimulation but remains hypothesis-generating.
Structured PICO
Do hypertension and hypercholesterolemia impair coronary vascular nitric oxide activity in response to endothelial stimulators in patients with angiographically normal coronary arteries?
P
Population
26 patients with angiographically normal coronary arteries, including 10 without risk factors and 16 with either hypertension (n=9) and/or hypercholesterolemia (n=10).
I
Intervention
Intracoronary dose-response curves with acetylcholine, substance P, and sodium nitroprusside before and after NG-monomethyl-L-arginine (L-NMMA).
C
Comparator
Patients without risk factors (for group comparison) and baseline responses before L-NMMA administration.
O
Outcome
Changes in epicardial coronary diameter and vascular resistance.surrogate
Hypertension and hypercholesterolemia are associated with impaired coronary endothelial nitric oxide bioavailability in response to both muscarinic and nonmuscarinic stimulators.
Cite This Study
Quyyumi et al. (1997) studied this question.