March 1, 1996Hypertension
Evidence for a Multifactorial Process Involved in the Impaired Flow Response to Nitric Oxide in Hypertensive Patients With Endothelial Dysfunction
Key result
Hypertension was associated with a significantly reduced maximum increase in resting forearm blood flow in response to sodium nitroprusside (-36%), acetylcholine (-44%), and bradykinin (-56%).
Why the study?
Does the dilatory response to endogenous and exogenous NO differ between hypertensive and normotensive individuals?
Population
29 individuals: 17 hypertensive patients and 12 normotensive individuals
Comparison
Application of NO donor sodium nitroprusside… vs Normotensive individuals
Design
Cross-sectional
Authors
Discussion
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Implication
Should not yet change hypertension management; leaves open heterogeneous NO pathway mechanisms and therapeutic targets.
Study Design
Type
Cross-Sectional (n=29)
Structured PICO
Does the dilatory response to endogenous and exogenous NO differ between hypertensive and normotensive individuals?
P
Population
29 participants comprising 17 hypertensive patients and 12 normotensive controls assessed for forearm dilatory response.
E
Exposure
Application of NO donor sodium nitroprusside, and stimulation of endogenous NO synthesis by acetylcholine and bradykinin
C
Comparator
Normotensive individuals
O
Outcome
Forearm blood flow quantified by venous occlusion plethysmography and blood flow velocity in cutaneous microvasculature measured with laser-Doppler flowmetrysurrogate
In hypertensive patients, the impairment of NO-dependent dilation of resistance arteries is heterogeneously impaired and caused by multiple mechanisms beyond just reduced NO synthesis.
Cite This Study
Kelm et al. (1996) conducted a cross-sectional in Hypertension (n=29). Hypertension vs. Normotensive individuals was evaluated on Maximum increase in resting forearm blood flow in response to sodium nitroprusside, acetylcholine, and bradykinin. Hypertension was associated with a significantly reduced maximum increase in resting forearm blood flow in response to sodium nitroprusside (-36%), acetylcholine (-44%), and bradykinin (-56%).