March 1, 1997Journal of Cardiovascular Pharmacology
Cutaneous Vasodilation to Acetylcholine in Patients with Essential Hypertension
Why the study?
Does acetylcholine infusion reveal impaired endothelium-dependent vasodilation in the skin microcirculation of patients with essential hypertension compared to normotensive controls?
Population
17 subjects: 9 patients with essential hypertension and 8 matched normotensive controls.
Comparison
Infusion of acetylcholine and sodium… vs Matched normotensive subjects receiving the same…
Design
Case-control
Authors
Discussion
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Implication
May indicate skin microvascular endothelial dysfunction in hypertension; hypothesis-generating and should not yet change practice.
Structured PICO
Does acetylcholine infusion reveal impaired endothelium-dependent vasodilation in the skin microcirculation of patients with essential hypertension compared to normotensive controls?
P
Population
17 subjects: 9 patients with essential hypertension and 8 matched normotensive controls.
I
Intervention
Infusion of acetylcholine (0.15, 0.45, 1.5, 4.5, and 15 microg/100 ml forearm tissue/min) and sodium nitroprusside (1, 2, and 4 microg/100 ml forearm tissue/min) into the brachial artery.
C
Comparator
Matched normotensive subjects (n=8) receiving the same infusions.
O
Outcome
Modifications in cutaneous blood flow (measured by laser Doppler flowmeter) and muscle blood flow (measured by strain-gauge venous plethysmography).surrogate
Patients with essential hypertension exhibit endothelial dysfunction in the skin microcirculation, as evidenced by reduced cutaneous vasodilation to acetylcholine.
Cite This Study
Rossi et al. (1997) studied this question.