April 1, 1992Journal of Cardiovascular Pharmacology
Endothelium-Dependent Forearm Vasodilation Is Reduced in Normotensive Subjects with Familial History of Hypertension
Why the study?
Is endothelium-dependent forearm vasodilation reduced in normotensive subjects with a familial history of essential hypertension?
Population
26 normotensive subjects, matched for age, sex, body weight, and blood pressure.
Comparison
Intra-arterial infusion of acetylcholine, sodium… vs Offspring of normotensive subjects.
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May indicate preclinical endothelial dysfunction in hypertension families; leaves open causal role and clinical utility.
Structured PICO
Is endothelium-dependent forearm vasodilation reduced in normotensive subjects with a familial history of essential hypertension?
P
Population
26 normotensive subjects (13 offspring of essential hypertensive subjects and 13 offspring of normotensive subjects), matched for age, sex, body weight, and blood pressure.
I
Intervention
Intra-arterial infusion of acetylcholine (0.15, 0.45, 1.5, 4.5, and 15 micrograms/100 ml of forearm tissue/min), sodium nitroprusside (1, 3, and 10 micrograms/100 ml of forearm tissue/min), and forearm ischemia (13 min plus 1 min of exercise).
C
Comparator
Offspring of normotensive subjects (control group).
O
Outcome
Response of forearm vasculature to acetylcholine (endothelium-dependent vasodilation) measured by strain-gauge venous plethysmography.surrogate
Endothelial dysfunction is present in normotensive individuals with a family history of essential hypertension, suggesting it may precede and contribute to the pathogenesis of hypertension.
Cite This Study
Taddei et al. (1992) studied this question.