January 1, 2002Blood PressureOpen Access

Endothelium-dependent Vasodilation in Normotensive Subjects with a Familial History of Essential Hypertension and in Young Subjects with Borderline Hypertension

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Why the study?

Does a familial history of essential hypertension or borderline hypertension impair endothelial function in young subjects?

Population

53 young subjects, including 15 healthy normotensive subjects with a familial history of essential…

Comparison

Local intra-arterial infusions of methacholine… vs Matched healthy normotensive subjects without a…

Design

Cross-sectional

Authors

JMJonas MillgårdSunderby sjukhus AHAnders HäggUppsala University MSMahziar SarabiUppsala University Hospital

Discussion

Member takes

Implication

Supports early endothelial involvement in hypertension risk; leaves open predictive value and intervention targets in normotensive youth.

Structured PICO

Does a familial history of essential hypertension or borderline hypertension impair endothelial function in young subjects?

Population

53 young subjects, including 15 healthy normotensive subjects with a familial history of essential hypertension (FHH) (age 26 +/- 4 years, BP 115 +/- 8/71 +/- 6 mmHg), 31 matched healthy normotensive subjects without FHH, and 7 borderline-hypertensive (BHT) young males (BP 143 +/- 12/92 +/- 2 mmHg).

Intervention

Local intra-arterial infusions of methacholine (MCh) and sodium nitroprusside (SNP) in the forearm to evaluate vasodilation.

Comparator

Matched healthy normotensive subjects without a familial history of essential hypertension (FHH).

Outcome

Endothelial function index (calculated as the ratio between endothelium-dependent vasodilation [EDV] and endothelium-independent vasodilation [EIDV]) and forearm blood flow (FBF) measured by venous occlusion plethysmography.surrogate

Endothelial dysfunction occurs early in the development of essential hypertension, even in young normotensive individuals with a family history of the disease.

Cite This Study

Millgård et al. (2002) studied this question.

synapsesocial.com/papers/6a795fafb2ad017e403209e2 https://doi.org/10.1080/080370502320779485

Topics

Hypertension management

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Endothelium-dependent Vasodilation in Normotensive Subjects with a Familial History of Essential Hypertension and in Young Subjects with Borderline Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Endothelium-dependent Vasodilation in Normotensive Subjects with a Familial History of Essential Hypertension and in Young Subjects with Borderline Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider