Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 11, 2004International Journal of Angiology

Noninvasive assessment of endothelial dysfunction in essential hypertension: Comparison of the forearm microvascular reactivity with flow-mediated dilatation of the brachial artery

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Is endothelium-dependent vasodilation in the forearm microcirculation related to flow-mediated dilation of the brachial artery in patients with essential hypertension?

Population

33 males, comprising 22 treated essential hypertensive patients with impaired FMD of the brachial artery…

Comparison

Assessment of forearm skin microcirculation and… vs Normotensive subjects (NT).

Design

Cross-sectional

Authors

KFKatalin FarkasSemmelweis UniversityEFEmília FábiánHudklinikkenEKEndre KolossvárySemmelweis University

Discussion

Loading...

Member takes

Implication

No association seen between microcirculatory endothelial function and brachial FMD in essential hypertension; leaves open distinct vascular bed responses.

Structured PICO

Is endothelium-dependent vasodilation in the forearm microcirculation related to flow-mediated dilation of the brachial artery in patients with essential hypertension?

P
Population
33 males, comprising 22 treated essential hypertensive patients (EHT) with impaired FMD of the brachial artery, and 11 normotensive subjects (NT).
I
Intervention
Assessment of forearm skin microcirculation (postocclusive reactive hyperemic response [PORH], acetylcholine [ACh], sodium nitroprusside [SNP]) and brachial artery flow-mediated dilation (FMD).
C
Comparator
Normotensive subjects (NT).
O
Outcome
Relationship between endothelium-dependent vasodilation in the forearm microcirculation (PORH and response to ACh) and endothelium-dependent flow-mediated dilation (FMD) of the brachial artery.surrogate

Endothelium-dependent vasodilation in the forearm microcirculation is not related to FMD of the brachial artery in essential hypertension, suggesting differences in vascular beds and hyperemic mechanisms.

Cite This Study

Farkas et al. (2004) studied this question.

synapsesocial.com/papers/6a7c512e5d0a07afc93be466https://doi.org/10.1007/s00547-003-1000-8
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nitric Oxide Is Responsible for Flow-Dependent Dilatation of Human Peripheral Conduit Arteries In Vivo1995 · 1,627 citations
  2. 2Assessment of microvascular endothelial function in human skin2001 · 71 citations
  3. 3Studies with iontophoretic administration of drugs to human dermal vessels in vivo: cholinergic vasodilatation is mediated by dilator prostanoids rather than nitric oxide1998 · 143 citations
  4. 4Vascular and neural mechanisms of ACh-mediated vasodilation in the forearm cutaneous microcirculation2002 · 121 citations
  5. 5Cutaneous Vascular Responses to Acetylcholine are Mediated by a Prostanoid-Dependent Mechanism in Man1997 · 70 citations