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November 14, 2000Clinical Physiology

Evaluation of endothelium‐dependent vasodilation in the human peripheral circulation

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Why the study?

Is there a correlation between flow-mediated vasodilation (FMD) and forearm blood flow (FBF) responses to methacholine for evaluating endothelium-dependent vasodilation in humans?

Population

38 individuals

Comparison

Measurement of endothelium-dependent… vs Measurement of flow-mediated vasodilation in the…

Design

Cross-sectional

Authors

LLLars LindUppsala UniversityJHJan HallUppsala University HospitalALAnders LarssonUppsala University

Discussion

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Implication

FMD and methacholine FBF should not be used interchangeably; leaves open whether they capture distinct endothelial pathways in cross-sectional data.

Structured PICO

Is there a correlation between flow-mediated vasodilation (FMD) and forearm blood flow (FBF) responses to methacholine for evaluating endothelium-dependent vasodilation in humans?

P
Population
38 individuals (26 evaluated with both FMD and FBF methods, 12 evaluated for NOx concentrations during MCh infusion)
I
Intervention
Measurement of endothelium-dependent vasodilation using forearm blood flow (FBF) induced by local infusion of methacholine (MCh) or L-arginine
C
Comparator
Measurement of flow-mediated vasodilation (FMD) in the brachial artery by ultrasound
O
Outcome
Correlation between FMD and FBF for evaluating endothelium-dependent vasodilationsurrogate

FMD and FBF with methacholine do not correlate for assessing endothelium-dependent vasodilation, despite methacholine-induced vasodilation being mediated by nitric oxide release.

Cite This Study

Lind et al. (2000) studied this question.

synapsesocial.com/papers/6a1bd87dfc87fd06169ce068https://doi.org/10.1046/j.1365-2281.2000.00281.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prostaglandin H2 as an endothelium-derived contracting factor and its interaction with endothelium-derived nitric oxide1991 · 77 citations
  2. 2Comparison of Cholinergic Vasodilator Responses to Acetylcholine and Methacholine in the Human Forearm1996 · 45 citations
  3. 3Reproducibility of brachial ultrasonography and flow‐mediated dilatation (FMD) for assessing endothelial function1997 · 73 citations
  4. 4Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility.1995 · 695 citations
  5. 5Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension1990 · 2,382 citations