What does this research mean for the field?

The measurement of endothelial function using the ratio of forearm blood flow during metacholine to sodium nitroprusside infusion is highly reproducible and independent of resting blood flow, arm dimensions, hand circulation exclusion, and maximal blood flow during reactive hyperemia. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1998Clinical Physiology

Methodological aspects of the evaluation of endothelium‐dependent vasodilatation in the human forearm

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Population

56 healthy subjects from a health screening, including a subset of 10 young volunteers for reproducibility…

Design

Cross-sectional

Follow-up

2 hours and 3 weeks (for reproducibility subset)

Authors

LLLind LindUppsala University SSarabiUppsala University Hospital MMillgårdUppsala University Hospital

Discussion

Member takes

Implication

Supports FBF reproducibility for endothelial research; leaves open clinical adoption pending higher-level validation.

Structured PICO

Population

56 healthy subjects from a health screening, including a subset of 10 young volunteers for reproducibility testing.

Intervention

Measurement of endothelial function using local intra-arterial infusions of metacholine (2 and 5 micrograms min-1) and sodium nitroprusside (5 and 10 micrograms min-1) via venous occlusion plethysmography.

Outcome

Influence of methodological factors (resting FBF, arm dimensions, wrist cuff use, reactive hyperaemia) on endothelial function index and its short- and long-term reproducibility.surrogate

Cite This Study

Lind et al. (1998) studied this question.

synapsesocial.com/papers/6a1bd87dfc87fd06169ce069 https://doi.org/10.1046/j.1365-2281.1998.00077.x

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March 1, 1998Clinical Physiology

Methodological aspects of the evaluation of endothelium‐dependent vasodilatation in the human forearm

View Full Paper

Ask AI

Bookmark

Population

56 healthy subjects from a health screening, including a subset of 10 young volunteers for reproducibility…

Design

Cross-sectional

Follow-up

2 hours and 3 weeks (for reproducibility subset)

Authors

LLLind LindUppsala University SSarabiUppsala University Hospital MMillgårdUppsala University Hospital

Discussion

Member takes

Implication

Supports FBF reproducibility for endothelial research; leaves open clinical adoption pending higher-level validation.

Structured PICO

Population

56 healthy subjects from a health screening, including a subset of 10 young volunteers for reproducibility testing.

Intervention

Outcome

Influence of methodological factors (resting FBF, arm dimensions, wrist cuff use, reactive hyperaemia) on endothelial function index and its short- and long-term reproducibility.surrogate

Cite This Study

Lind et al. (1998) studied this question.

synapsesocial.com/papers/6a1bd87dfc87fd06169ce069 https://doi.org/10.1046/j.1365-2281.1998.00077.x

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