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April 22, 2002Clinical Science

Evaluation of four different methods to measure endothelium-dependent vasodilation in the human peripheral circulation

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Key result

The reduction in the radial pulse wave inflection point was significantly related to both EDV (r=-0.41) and EIDV (r=-0.42) measured by the invasive forearm technique (P<0.05).

Why the study?

How do four different methods for measuring endothelium-dependent vasodilation in the human peripheral circulation correlate with each other in young, healthy subjects?

Population

24 young, healthy subjects

Comparison

Evaluation of four methods to measure… vs Comparison among the four methods

Design

Cross-sectional

Authors

LLLars LindJHJan HallKJKristina Johansson

Discussion

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Overview

Pulse wave inflection reduction associates with invasive EDV/EIDV; leaves open its specificity versus other methods and clinical utility.

Study Design

Type

Cross-Sectional (n=24)

Structured PICO

How do four different methods for measuring endothelium-dependent vasodilation in the human peripheral circulation correlate with each other in young, healthy subjects?

P
Population
24 young, healthy subjects
I
Intervention
Evaluation of four methods to measure endothelium-dependent vasodilation: invasive forearm technique with local infusion of methacholine and sodium nitroprusside, brachial artery flow-mediated vasodilation (FMD) by ultrasound, FMD with ischaemic hand exercise, and radial pulse wave inflection point reduction following beta(2)-adrenergic receptor stimulation
C
Comparator
Comparison among the four methods
O
Outcome
Relationships (correlations) between the four techniques for measuring endothelium-dependent vasodilationsurrogate

Main Result

Effect estimate: r=-0.41 and r=-0.42

p-value: p=<0.05

Different methods of measuring endothelium-dependent vasodilation do not correlate well, suggesting that endothelial function differs between conduit and resistance arteries and that the pulse wave technique is not specific to EDV.

Cite This Study

Lind et al. (2002) conducted a cross-sectional in Healthy (n=24). Four methods to measure endothelium-dependent vasodilation was evaluated on Correlation between measurement techniques for endothelium-dependent vasodilation (r=-0.41 and r=-0.42, p=<0.05). The reduction in the radial pulse wave inflection point was significantly related to both EDV (r=-0.41) and EIDV (r=-0.42) measured by the invasive forearm technique (P<0.05).

synapsesocial.com/papers/6a129bb4c031bb6829a6f704https://doi.org/10.1042/cs1020561
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Comparison of Three Different Methods to Evaluate Endothelium-Dependent Vasodilation in the Elderly2005 · 365 citations
  2. 2Relationships between three different tests to evaluate endothelium-dependent vasodilation and cardiovascular risk in a middle-aged sample2013 · 57 citations
  3. 3Evaluation of endothelium‐dependent vasodilation in the human peripheral circulation2000 · 99 citations
  4. 4Methodological aspects of the evaluation of endothelium‐dependent vasodilatation in the human forearm1998 · 110 citations
  5. 5Noninvasive assessment of endothelial dysfunction in essential hypertension: Comparison of the forearm microvascular reactivity with flow-mediated dilatation of the brachial artery2004 · 9 citations