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April 26, 2013Journal of Hypertension

Relationships between three different tests to evaluate endothelium-dependent vasodilation and cardiovascular risk in a middle-aged sample

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Why the study?

How do FMD, EDV, and PAT correlate with each other and with cardiovascular risk assessed by the Framingham risk score in middle-aged individuals?

Population

222 individuals aged 50 years from the population-based Prospective investigation of Obesity, Energy and…

Design

Cross-sectional

Authors

LLLars Lind

Discussion

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Overview

Endothelial tests lack correlation and show inconsistent Framingham associations; leaves open their comparative prognostic utility.

Structured PICO

How do FMD, EDV, and PAT correlate with each other and with cardiovascular risk assessed by the Framingham risk score in middle-aged individuals?

P
Population
222 individuals aged 50 years (50% women) from the population-based Prospective investigation of Obesity, Energy and Metabolism (POEM) study.
I
Intervention
Assessment of endothelium-dependent vasodilation using three techniques: flow-mediated vasodilation (FMD), acetylcholine-mediated vasodilation (EDV), and peripheral artery tonometry (PAT).
O
Outcome
Relationships between the three vasodilation tests and their correlation with the Framingham risk score.surrogate

Different tests of endothelium-dependent vasodilation do not correlate with each other, and only FMD and EDV (but not PAT) correlate with the Framingham risk score in middle-aged individuals.

Cite This Study

Lars Lind (2013) studied this question.

synapsesocial.com/papers/6a75ef1df56d87d9178b7428https://doi.org/10.1097/hjh.0b013e3283619d50
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Comparison of Three Different Methods to Evaluate Endothelium-Dependent Vasodilation in the Elderly2005 · 365 citations
  2. 2Evaluation of four different methods to measure endothelium-dependent vasodilation in the human peripheral circulation2002 · 53 citations
  3. 3Endothelial function assessment in atherosclerosis. Comparison of brachial artery flow‑mediated vasodilation and peripheral arterial tonometry2013 · 81 citations
  4. 4Testing Endothelial Function and its Clinical Relevance2012 · 119 citations
  5. 5Noninvasive assessment of endothelial dysfunction in essential hypertension: Comparison of the forearm microvascular reactivity with flow-mediated dilatation of the brachial artery2004 · 9 citations