Key result
Flow-mediated dilation was significantly correlated with intima-media thickness (r = -0.53) and atherosclerotic risk factors, whereas reactive hyperemia index showed no such correlations despite correlating modestly with FMD (r = 0.35).
Why the study?
Does reactive hyperemia-peripheral artery tonometry (RH-PAT) correlate with flow-mediated dilation (FMD) and atherosclerotic risk factors in subjects with moderate-to-low cardiovascular risk?
Population
80 subjects aged 43.6 ±14.8 years, with moderate-to-low cardiovascular risk.
Comparison
Reactive hyperemia-peripheral artery tonometry… vs Brachial artery flow-mediated dilation (FMD)
Design
Cross-sectional
Authors
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FMD may better capture atherosclerotic risk than RH-PAT; leaves open whether RH-PAT adds incremental value in moderate-to-low risk groups.
Observational (n=80)
No
Does reactive hyperemia-peripheral artery tonometry (RH-PAT) correlate with flow-mediated dilation (FMD) and atherosclerotic risk factors in subjects with moderate-to-low cardiovascular risk?
Effect estimate: r = 0.35
p-value: p=<0.01
Although RH-PAT correlates modestly with FMD, FMD remains a more sensitive method for evaluating the impact of classical atherosclerotic risk factors on vascular endothelial function.
Wilk et al. (2013) conducted an observational in Atherosclerosis risk (n=80). Brachial artery flow-mediated dilation (FMD) and reactive hyperemia-peripheral artery tonometry (RH-PAT) was evaluated on Correlation between reactive hyperemia index (RHI) and flow-mediated dilation (FMD) (r = 0.35, p=<0.01). Flow-mediated dilation was significantly correlated with intima-media thickness (r = -0.53) and atherosclerotic risk factors, whereas reactive hyperemia index showed no such correlations despite correlating modestly with FMD (r = 0.35).
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