What question did this study set out to answer?

To determine whether non-invasive assessment of endothelial function in conduit arteries reflects the in vitro endothelial function and structure of resistance arteries in essential hypertension.

March 1, 2001Journal of Hypertension

Correlation of endothelial function in large and small arteries in human essential hypertension.

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Why the study?

Does non-invasive measurement of endothelial function in conduit arteries reflect that of subcutaneous resistance arteries in patients with essential hypertension?

Population

16 patients with essential hypertension, mean age 50 +/- 2 years.

Comparison

Non-invasive measurement of brachial artery… vs In vitro measurement of endothelial function in…

Design

Cross-sectional

Authors

JPJeong Bae ParkYonsei University FCFrançois CharbonneauFondation Ophtalmologique Adolphe de Rothschild ESErnesto L. SchiffrinMedical Council of Canada

Discussion

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Implication

Brachial FMD may reflect resistance artery endothelial function in hypertension; supports its use as a surrogate but remains hypothesis-generating.

Key Points

To determine whether non-invasive assessment of endothelial function in conduit arteries reflects the in vitro endothelial function and structure of resistance arteries in essential hypertension.
Assessed brachial artery flow-mediated dilation (FMD) via ultrasound during reactive hyperemia and sublingual nitroglycerin dilation in N=16 essential hypertensive patients (aged 50 ± 2 years).
Evaluated vascular structure and in vitro vasorelaxation responses to acetylcholine and sodium nitroprusside in gluteal subcutaneous resistance arteries using pressurized myography.
Resistance arteries of hypertensive patients exhibited an increased media:lumen ratio (8.6 ± 0.4% vs. 5.9 ± 0.3% in normotensives, P < 0.01) and blunted maximal acetylcholine-induced vasorelaxation (75 ± 6% vs. 97 ± 2%, P < 0.01).
Brachial FMD significantly correlated with maximal acetylcholine-induced vasorelaxation in resistance arteries (r2 = 0.57, P < 0.001) but not with the media:lumen ratio (r2 = -0.22, P = 0.07).
Multivariate analysis confirmed that brachial FMD independently predicted resistance artery endothelial function after adjusting for age, sex, BMI, blood lipids, and baseline brachial diameter (beta = 0.81, P < 0.001).

Structured PICO

Does non-invasive measurement of endothelial function in conduit arteries reflect that of subcutaneous resistance arteries in patients with essential hypertension?

Population

16 patients with essential hypertension, mean age 50 +/- 2 years.

Intervention

Non-invasive measurement of brachial artery flow-mediated dilation (FMD) by ultrasound.

Comparator

In vitro measurement of endothelial function in subcutaneous resistance arteries from gluteal biopsies.

Outcome

Correlation between brachial artery FMD and maximal acetylcholine-induced vasorelaxation in resistance arteries.surrogate

Non-invasive measurement of brachial artery FMD correlates with in vitro endothelial function of resistance arteries, suggesting endothelial dysfunction is a generalized alteration in essential hypertension.

Cite This Study

Park et al. (2001) studied this question.

synapsesocial.com/papers/6a759869d17bc701ee161018 https://doi.org/10.1097/00004872-200103000-00009

Topics

Hypertension management

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Implication

Brachial FMD may reflect resistance artery endothelial function in hypertension; supports its use as a surrogate but remains hypothesis-generating.

Correlation of endothelial function in large and small arteries in human essential hypertension.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Correlation of endothelial function in large and small arteries in human essential hypertension.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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