Key result
Mild essential hypertensive patients with normal intima-media thickness had significantly reduced flow-mediated vasodilation (3.4% vs 16.5%, P<0.01) compared to normotensive controls.
Population
33 subjects including 10 never treated mild essential hypertensive patients with normal carotid artery IMT…
Design
Cross-sectional
Authors
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May indicate endothelial dysfunction precedes IMT changes in mild hypertension; hypothesis-generating and requires prospective validation before clinical adoption.
Observational (n=33)
Absolute Event Rate: 3.4% vs 16.5%
p-value: p=<0.01
Endothelial dysfunction and reduced distensibility of large arteries in essential hypertension occur prior to and independent of structural vessel wall alterations like intima-media thickening.
Michael Barenbrock (1999) conducted an observational in Mild essential hypertension (n=33). Mild essential hypertension vs. Normotensive control subjects was evaluated on Flow-mediated vasodilation after forearm occlusion (p=<0.01). Mild essential hypertensive patients with normal intima-media thickness had significantly reduced flow-mediated vasodilation (3.4% vs 16.5%, P<0.01) compared to normotensive controls.
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