What question did this study set out to answer?

This study investigates the relationship between carotid artery structure and blood flow in hypertensive patients.

March 1, 1995Stroke

Carotid Diameter and Blood Flow Velocities in Cerebral Circulation in Hypertensive Patients

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Why the study?

Does uncomplicated hypertension alter carotid diameter, parietal stress, and cerebral blood flow velocities compared to normotensive controls?

Population

70 hypertensive patients without clinical evidence of target organ damage, and age- and sex-matched…

Comparison

Hypertension (observational exposure) vs Age- and sex-matched normotensive control subjects

Design

Case-control

Authors

LFL FerraraPolitecnico di Milano MMMarcello ManciniInstitute of Biostructure and Bioimaging RIR. IannuzziUniversity of Naples Federico II

Discussion

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Implication

Reduced carotid-to-pressure ratio in uncomplicated hypertension signals early remodeling; leaves open links to cerebrovascular risk pending prospective data.

Key Points

This study investigates the relationship between carotid artery structure and blood flow in hypertensive patients.
Sample size of 70 hypertensive patients without target organ damage was analyzed.
Carotid artery diameter and blood flow velocities were measured using ultrasound and Doppler techniques.
Pulsatility and resistance indexes were calculated from the measurements.
Carotid diameter ratio to blood pressure was significantly reduced in hypertensive patients (5.3 +/- 0.7 vs. 6.5 +/- 0.8, P < .001).
A slight but significant increase in mean velocity of internal carotid artery in hypertensive patients (37.5 +/- 9.1 vs. 32.7 +/- 3.0 cm/s, P < .02).
Increased parietal stress correlated with diameter in normotensive but not in hypertensive patients.

Structured PICO

Does uncomplicated hypertension alter carotid diameter, parietal stress, and cerebral blood flow velocities compared to normotensive controls?

Population

70 hypertensive patients without clinical evidence of target organ damage, and age- and sex-matched normotensive control subjects

Intervention

Hypertension (observational exposure)

Comparator

Age- and sex-matched normotensive control subjects

Outcome

Carotid artery diameter, blood flow velocities in common carotid, internal carotid, and middle cerebral arteries, and parietal stresssurrogate

Uncomplicated hypertension is associated with early impairment in the relationship between carotid artery diameter and parietal stress, as well as increased internal carotid flow velocity.

Cite This Study

Ferrara et al. (1995) studied this question.

synapsesocial.com/papers/6a734f5755b155b8bdf12d30 https://doi.org/10.1161/01.str.26.3.418

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Implication

Reduced carotid-to-pressure ratio in uncomplicated hypertension signals early remodeling; leaves open links to cerebrovascular risk pending prospective data.

Carotid Diameter and Blood Flow Velocities in Cerebral Circulation in Hypertensive Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Carotid Diameter and Blood Flow Velocities in Cerebral Circulation in Hypertensive Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider