What question did this study set out to answer?

To determine whether flow-dependent vasodilation in the brachial artery is altered in patients with essential hypertension compared to normotensive individuals.

April 1, 1990AJP Heart and Circulatory Physiology

Flow-dependent vasodilation of brachial artery in essential hypertension

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Why the study?

Is flow-dependent vasodilation of the brachial artery impaired in patients with essential hypertension compared to normotensive subjects?

Population

34 subjects (15 normotensive subjects and 19 age-matched patients with essential hypertension)

Comparison

2-minute period of distal circulatory occlusion… vs Normotensive subjects

Design

Cross-sectional

Authors

SLS. LaurentBicêtre Hospital PLPatrick LacolleyVascular Medicine PBPatrick BrunelÉcole Nationale de la Météorologie

Discussion

Member takes

Implication

May support preserved velocity-dependent vasodilation in essential hypertension; leaves open confirmation in prospective endothelial studies.

Key Points

To determine whether flow-dependent vasodilation in the brachial artery is altered in patients with essential hypertension compared to normotensive individuals.
Assessed brachial artery diameter and local blood flow velocity noninvasively using a bidimensional pulsed Doppler system.
Evaluated 15 normotensive subjects and 19 age-matched patients with essential hypertension at rest, during a 2-minute distal circulatory occlusion, and during reactive hyperemia.
Distal circulatory occlusion led to significant decreases in both blood flow velocity and arterial diameter in normotensive and hypertensive groups.
Reactive hyperemia induced comparable peak blood flow velocities and significant diameter increases across both cohorts, with diameter changes positively and significantly correlated with velocity changes without significant intergroup differences.

Structured PICO

Is flow-dependent vasodilation of the brachial artery impaired in patients with essential hypertension compared to normotensive subjects?

Population

34 subjects (15 normotensive subjects and 19 age-matched patients with essential hypertension)

Intervention

2-minute period of distal circulatory occlusion and reactive hyperemia

Comparator

Normotensive subjects

Outcome

Kinetics of changes in brachial artery diameter (D) and local blood flow velocity (V)surrogate

Velocity-dependent vasodilation of the brachial artery is not impaired in patients with essential hypertension.

Cite This Study

Laurent et al. (1990) studied this question.

synapsesocial.com/papers/6a855e0db605bb00f9d4c499 https://doi.org/10.1152/ajpheart.1990.258.4.h1004

Topics

Hypertension management

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Implication

May support preserved velocity-dependent vasodilation in essential hypertension; leaves open confirmation in prospective endothelial studies.

Flow-dependent vasodilation of brachial artery in essential hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Flow-dependent vasodilation of brachial artery in essential hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider