Why the study?
Does norepinephrine alter large artery hemodynamics differently in patients with essential hypertension compared to normotensive subjects?
Population
28 subjects (19 patients with essential hypertension and 9 normotensive subjects)
Comparison
Norepinephrine (10, 20, and 40 ng.kg-1.min-1 iv) vs Placebo (glucose) and normotensive control group
Design
Other, single-blind
Authors
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May heighten caution with vasopressors in hypertension; supports increased large-artery reactivity but remains hypothesis-generating.
Does norepinephrine alter large artery hemodynamics differently in patients with essential hypertension compared to normotensive subjects?
Essential hypertension is associated with increased vascular reactivity to norepinephrine in large arteries, impairing their conducting and buffering functions.
Laurent et al. (1988) studied this question.
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