Why the study?
Does intrinsic vascular responsiveness to agonists differ between normotensive and hypertensive subjects in isolated human cystic arteries?
Population
Isolated helical cut strips of cystic artery (downstream branch of hepatic artery) from 120 subjects
Comparison
Exposure to norepinephrine, transmural… vs Arteries from normotensive subjects versus…
Design
Preclinical
Authors
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May indicate female-specific norepinephrine hyperresponsiveness in hypertension; hypothesis-generating and requires human confirmation before clinical consideration.
Does intrinsic vascular responsiveness to agonists differ between normotensive and hypertensive subjects in isolated human cystic arteries?
Alteration in intrinsic vascular responsiveness to norepinephrine may play a role in the pathogenesis of human essential hypertension, particularly in females.
George Wyse (1984) studied this question.
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