Why the study?
Do subcutaneous resistance arteries from patients with primary hypertension show altered contractility or endothelium-derived relaxing factor responses compared to normotensive controls?
Do subcutaneous resistance arteries from patients with primary hypertension show altered contractility or endothelium-derived relaxing factor responses compared to normotensive controls?
Subcutaneous resistance arteries from patients with essential hypertension demonstrate enhanced contractility to vasoconstrictors and nerve stimulation without detectable medial hypertrophy or defects in endothelium-derived relaxing factor.
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Animal data link hypercontractility to hypertension without hypertrophy or EDRF loss; leaves open human relevance and therapeutic implications.
Angus et al. (1992) studied this question.
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