July 1, 1994HypertensionOpen Access

In vitro perfusion studies of human resistance artery function in essential hypertension.

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Why the study?

Are morphological and functional characteristics of isolated human subcutaneous small arteries altered in essential hypertension compared to normotensive controls?

Population

Isolated human subcutaneous small arteries from 17 essential hypertensive patients and 14 normotensive…

Comparison

In vitro perfusion myograph assessment of… vs Arteries from normotensive control subjects

Design

Preclinical

Authors

BFB J FalloonUniversity of Manchester AHAnthony M. HeagertyPreventive Cardiology

Discussion

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Implication

Impaired endothelium-dependent relaxation supports endothelial dysfunction in essential hypertension; hypothesis-generating in isolated arteries and leaves clinical implications open.

Structured PICO

Are morphological and functional characteristics of isolated human subcutaneous small arteries altered in essential hypertension compared to normotensive controls?

Population

Isolated human subcutaneous small arteries from 17 essential hypertensive patients and 14 normotensive control subjects (n=31)

Intervention

In vitro perfusion myograph assessment of vascular reactivity to norepinephrine, acetylcholine, and sodium nitroprusside

Comparator

Arteries from normotensive control subjects

Outcome

Morphological characteristics (media thickness to lumen diameter ratio) and functional characteristics (sensitivity to norepinephrine, acetylcholine, and sodium nitroprusside)surrogate

The study demonstrates defective endothelium-dependent dilatation in human resistance arteries in essential hypertension, highlighting the role of endothelial dysfunction.

Cite This Study

Falloon et al. (1994) studied this question.

synapsesocial.com/papers/6a82120860b4a58d31d243ce https://doi.org/10.1161/01.hyp.24.1.16

Topics

Hypertension management

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Implication

Impaired endothelium-dependent relaxation supports endothelial dysfunction in essential hypertension; hypothesis-generating in isolated arteries and leaves clinical implications open.

In vitro perfusion studies of human resistance artery function in essential hypertension.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

In vitro perfusion studies of human resistance artery function in essential hypertension.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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